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PROTECTION AGAINST ENDOCRINE DISRUPTORS

Publications

Publications

A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) differentially affect glutamate induced excitotoxic responses in chicken cerebellum granule neurons (CGNs) in vitro - ScienceDirect

MARCH 01, 2021

AjayYadavabStevenVerhaegenaEvelienVerbruggenbMarieKerhoasbEva HenriëtteWillemijn HuibertsbMussie GhezuHaderabHanne FriisBerntsenacKarin ElisabethZimmerdErikRopstadaRagnhild ElisabethPaulsenb

 

A human relevant mixture of persistent organic pollutants (POPs) and perfluorooctane sulfonic acid (PFOS) enhance nerve growth factor (NGF)-induced neurite outgrowth in PC12 cells

MARCH 01, 2021

AjayYadavabMaziaAmbercDenisZosenbNils AndersLabbabEva Henriette WillemijnHuibertsbJohannaSamulin ErdemdFredHaugendHanne FriisBerntsenadShanbehZienolddinydRagnhild ElisabethPaulsenbErikRopstadaLisaConnollycStevenVerhaegena

The insulin-like growth factor system: A target for endocrine disruptors?

FEBRUARY 01, 2021

Chiara Tallia, Lisa Connolly, Paul A. Fowler 

Induction of AhR transactivation by PBDD/Fs and PCDD/Fs using a novel human-relevant, high-throughput DR human CALUX reporter gene assay

JANUARY 01, 2021

Clémence Budin 1Harrie Besselink 2Barbara M A van Vugt-Lussenburg 2Hai-Yen Man 2Bart van der Burg 2Abraham Brouwer 3_

 

Microcystins and Microcystis aeruginosa PCC7806 extracts modulate steroidogenesis differentially in the human H295R adrenal model

DECEMBER 15, 2020

Vittoria Mallia, Steven Verhaegen, Bjarne Styrishave, Gunnar Sundstøl Eriksen, Malene Louise Johannsen, Erik Ropstad, Silvio Uhlig

Targeting the aryl hydrocarbon receptor with a novel set of triarylmethanes

DECEMBER 01, 2020

ElizabethGoya-JorgeabCelineRampalcNicolasLoonescStephen J.BarigyebLaureano E.CarpiobRafaelGozalbesbClotildeFerroudcMaitéSylla-Iyarreta VeitíacRosa M.Ginera

Antagonistic activity towards the androgen receptor independent from natural sex hormones in human milk samples from the Norwegian HUMIS cohort

OCTOBER 01, 2020

Bérénice Collet, Barbara M.A. van Vugt-Lussenburg, Kees Swart, Rick Helmus, Matthijs Naderman, Eva de Rijke, Merete Eggesbø, Abraham Brouwer, Bart van der Burg

Predictive modeling of aryl hydrocarbon receptor (AhR) agonism

OCTOBER 01, 2020

ElizabethGoya-JorgeabRosa M.GinerbMaitéSylla-Iyarreta VeitíacRafaelGozalbesaStephen J.Barigyea

Discovery of 2-aryl and 2-pyridinylbenzothiazoles endowed with antimicrobial and aryl hydrocarbon receptor agonistic activities

AUGUST 01, 2020

ElizabethGoya-Jorgeab1FatmaAbdmoulehcd1Laureano E.CarpiobRosa M.GineraMaitéSylla-Iyarreta Veitíac

 

Detection of high PBDD/Fs levels and dioxin-like activity in toys using a combination of GC-HRMS, rat-based and human-based DR CALUX® reporter gene assays

JULY 01, 2020

Clémence Budin, Jindrich Petrlik, Jitka Strakova, Stephan Hamm, Bjorn Beeler, Peter Behnisch, Harrie Besselink, Bart van der Burg, Abraham Brouwer 

Testing the twin testosterone transfer hypothesis—intergenerational analysis of 317 dizygotic twins born in Aberdeen, Scotland

JUNE 19, 2020

Chiara Talia1 , Edwin-Amalraj Raja2 , Sohinee Bhattacharya2 , and Paul A. Fowler1

DMSO effects larval zebrafish (Danio rerio) behavior, with additive and interaction effects when combined with positive controls

MARCH 20, 2020

Maria Christou, Arturas Kavaliauskis, Erik Ropstad, Thomas William Kenneth Fraser 

Investigation of In Vitro Endocrine Activities of Microcystis and Planktothrix Cyanobacterial Strains

FEBRUARY 27, 2020

Vittoria Mallia, 1,2,*,Lada Ivanova 1,Gunnar S. Eriksen 1,Emma Harper 3,Lisa Connolly 3 and Silvio Uhlig 1

Acute Exposure to Zearalenone Disturbs Intestinal Homeostasis by Modulating the Wnt/β-Catenin Signaling Pathway

FEBRUARY 11, 2020

Tarek Lahjouji, Aurora Bertaccini, Manon Neves, Sylvie Puel, Isabelle P. Oswald, Laura Soler

 

Elucidating the aryl hydrocarbon receptor antagonism from a chemical-structural perspective

JANUARY 09, 2020

E. Goya-Jorge, T.Q. Doan, M.L. Scippo, M. Muller, R.M. Giner, S.J. Barigye, R. Gozalbes

Novel Microcystins from Planktothrix prolifica NIVA-CYA 544 Identified by LC-MS/MS, Functional Group Derivatization and 15N-labeling

NOVEMBER 15, 2019

Vittoria Mallia 1,2,*, Silvio Uhlig 1 , Cheryl Rafuse 3 , Juris Meija 4 and Christopher O. Miles 3

 

 

Comparative In Vitro Assessment of a Range of Commercial Feed Additives with Multiple Mycotoxin Binding Claims

NOVEMBER 12, 2019

Kolawole,  Meneely,  Greer,  Chevallier,  Jones,  Connolly,  Elliott

Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation

NOVEMBER 01, 2019

J.McCombaI.G.MillsbgM.MullercH.F.BerntsendeK.E.ZimmerfE.RopstaddS.VerhaegendL.Connollya

A mixture of persistent organic pollutants relevant for human exposure inhibits the transactivation activity of the aryl hydrocarbon receptor in vitro

NOVEMBER 01, 2019

T.Q. Doan, H.F. Berntsen, S. Verhaegen, E. Ropstad, L. Connolly, A. Igout, M. Muller, M.L. Scippo

Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation

NOVEMBER 01, 2019

J. McComb, I.G. Mills, M. Muller, H.F. Berntsen, K.E. Zimmer, E. Ropstad, S. Verhaegen, L. Connolly

Human-Based Exposure Levels of Perfluoroalkyl Acids May Induce Harmful Effects to Health by Disrupting Major Components of Androgen Receptor Signalling In Vitro

AUGUST 21, 2019

J. McComb, I. G. Mills, Hanne Friis Berntsen, E. Ropstad, S. Verhaegen & L. Connolly

Protection against Endocrine Disruptors; detection, mixtures, health effects, effects, risk assessment and communication.

Lisa Connolly, Jodie Wilson, Moira Dean, Chris Elliott, Merete Eggesbø, Paul Fowler,Erik Ropstad, Steven Verhaegen, Karin Zimmer, Thomas Fraser, Katrine Eldegard, Isabelle Oswald, Gudrun Kausel, Gunnar Eriksen, Silvio Uhlig, Marc Muller, Marie -Louise Scippo, Bart Van der Burg, Rafael Gozalbes, Declan Billington, Marc Ruelle, Siddhartha Mandal.

 

The Poster presented at COW2017 can be obtained here: COW17 Poster

 

 

The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals.

The fetal ovary exhibits temporal sensitivity to a ‘real-life’ mixture of environmental chemicals. Scientific Reports; 6, 22279.

Lea, R.G., Amezaga, M.R., Loup, B., Mandon-Pépin, B., Stefansdottir, A., Filis, P., Kyle, C., Zhang, Z., Allen, C., Purdie, L., Jouneau, L., Cotinot, C., Rhind, S.M., Sinclair, K.D., Fowler, P.A. (2016). 

Effects of defined mixtures of persistent organic pollutants (pops) on multiple cellular responses in the human hepatocarcinoma cell line, hepg2, using high content analysis screening.

Effects of defined mixtures of persistent organic pollutants (POPs) on multiple cellular responses in the human hepatocarcinoma cell line, HepG2, using high content analysis screening. Toxicology and Applied Pharmacology; 294, 21–31.

Wilson, J., Berntsen, H.F., Zimmer, K.E., Frizzell, C., Verhaegen, S., Ropstad, E., Connolly, L. (2016). 

In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia.

In vitro bioassay investigations of the endocrine disrupting potential of steviol glycosides and their metabolite steviol, components of the natural sweetener Stevia. Molecular and Cellular Endocrinology; 427, 65–72

Shannon, M., Rehfeld, A., Frizzell, C., Livingstone,C., McGonagle, C., Skakkebaek, N., Wielogórska, E., Connolly, L. (2016). 

 

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